Vol. 7, Issue 1, Part A (2025)

Background: Early hip osteoarthritis (OA) in young adults is increasingly recognized and demands joint-preserving strategies. This study evaluates a stepwise, multimodal protocol (PRP or HA with ozone ± diagnostic block; RFA for non‑responders) for pain relief and functional recovery.
Methods: Prospective single‑arm cohort of 24 patients (28 hips) with Tönnis Grade 0-2 hip OA. Day‑0 injection (leukocyte‑poor PRP 4 mL or high‑MW HA 2 mL) + ozone (10 mL at 20 µg/mL) under C‑arm guidance; RFA (femoral/obturator articular branches) at 2 weeks for <50% VAS responders. Outcomes: VAS, Harris Hip Score (HHS), WOMAC at 2, 6, 12 weeks, 6 months, and 1 year.
Results: Mean VAS improved from 7.4±0.8 to 2.3±1.0 at 1 year (p<0.001); HHS from 56.7±6.1 to 83.9±7.8 (p<0.001); WOMAC from 68.5±8.3 to 34.7±6.9 (p<0.001). Two‑thirds improved after injections alone; one‑third required RFA and achieved comparable 1‑year outcomes. Radiographs (6‑month, 1‑year) showed maintained joint space without progression.
Conclusion: A multimodal protocol combining orthobiologics, ozone, and selective RFA yields clinically meaningful, durable benefits in early hip OA and is a safe, joint‑preserving option in young adults.